Ontology highlight
ABSTRACT:
SUBMITTER: Wu Q
PROVIDER: S-EPMC3434346 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Wu Qixi Q He Runsheng R Zhou Haining H Yu Albert C H AC Zhang Bo B Teng Junlin J Chen Jianguo J
Cell research 20120417 9
Formation of a bipolar spindle is indispensable for faithful chromosome segregation and cell division. Spindle integrity is largely dependent on the centrosome and the microtubule network. Centrosome protein Cep57 can bundle microtubules in mammalian cells. Its related protein (Cep57R) in Xenopus was characterized as a stabilization factor for microtubule-kinetochore attachment. Here we show that Cep57 is a pericentriolar material (PCM) component. Its interaction with NEDD1 is necessary for the ...[more]