Ontology highlight
ABSTRACT:
SUBMITTER: Hsu WH
PROVIDER: S-EPMC6073210 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
EMBO reports 20180619 8
Bipolar spindle assembly is necessary to ensure the proper progression of cell division. Loss of spindle pole integrity leads to multipolar spindles and aberrant chromosomal segregation. However, the mechanism underlying the maintenance of spindle pole integrity remains unclear. In this study, we show that the actin-binding protein adducin-1 (ADD1) is phosphorylated at S726 during mitosis. S726-phosphorylated ADD1 localizes to centrosomes, wherein it organizes into a rosette-like structure at th ...[more]