Ontology highlight
ABSTRACT:
SUBMITTER: Richter C
PROVIDER: S-EPMC3434479 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Richter Christine C Messerschmidt Sylvia S Holeiter Gerlinde G Tepperink Jessica J Osswald Sylvia S Zappe Andrea A Branschädel Marcus M Boschert Verena V Mann Derek A DA Scheurich Peter P Krippner-Heidenreich Anja A
Molecular and cellular biology 20120430 13
The family of tumor necrosis factor receptors (TNFRs) and their ligands form a regulatory signaling network that controls immune responses. Various members of this receptor family respond differently to the soluble and membrane-bound forms of their respective ligands. However, the determining factors and underlying molecular mechanisms of this diversity are not yet understood. Using an established system of chimeric TNFRs and novel ligand variants mimicking the bioactivity of membrane-bound TNF ...[more]