Ontology highlight
ABSTRACT:
SUBMITTER: Michalik S
PROVIDER: S-EPMC3434780 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Molecular & cellular proteomics : MCP 20120503 9
The cellular amount of proteins not only depends on synthesis but also on degradation. Here, we expand the understanding of differential protein levels by complementing synthesis data with a proteome-wide, mass spectrometry-based stable isotope labeling with amino acids in cell culture analysis of protein degradation in the human pathogen Staphylococcus aureus during glucose starvation. Monitoring protein stability profiles in a wild type and an isogenic clpP protease mutant revealed that 1) pro ...[more]