Ontology highlight
ABSTRACT:
SUBMITTER: Michino M
PROVIDER: S-EPMC5234269 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Chemical communications (Cambridge, England) 20150501 41
To understand the structural basis for the Na(+)-sensitivity of ligand binding to dopamine D2-like receptors, using computational analysis in combination with binding assays, we identified interactions critical in propagating the impact of Na(+) on receptor conformations and on the ligand-binding site. Our findings expand the pharmacologically-relevant conformational spectrum of these receptors. ...[more]