Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors.
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ABSTRACT:
SUBMITTER: Michino M
PROVIDER: S-EPMC5234269 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
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Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors.
Michino Mayako M Free R Benjamin RB Doyle Trevor B TB Sibley David R DR Shi Lei L
Chemical communications (Cambridge, England) 20150501 41
To understand the structural basis for the Na(+)-sensitivity of ligand binding to dopamine D2-like receptors, using computational analysis in combination with binding assays, we identified interactions critical in propagating the impact of Na(+) on receptor conformations and on the ligand-binding site. Our findings expand the pharmacologically-relevant conformational spectrum of these receptors. ...[more]
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