Ontology highlight
ABSTRACT:
SUBMITTER: Kawabe Y
PROVIDER: S-EPMC3438319 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Kawabe Yoh-Ichi Y Wang Yu Xin YX McKinnell Iain W IW Bedford Mark T MT Rudnicki Michael A MA
Cell stem cell 20120802 3
In skeletal muscle, asymmetrically dividing satellite stem cells give rise to committed satellite cells that transcribe the myogenic determination factor Myf5, a Pax7-target gene. We identified the arginine methyltransferase Carm1 as a Pax7 interacting protein and found that Carm1 specifically methylates multiple arginines in the N terminus of Pax7. Methylated Pax7 directly binds the C-terminal cleavage forms of the trithorax proteins MLL1/2 resulting in the recruitment of the ASH2L:MLL1/2:WDR5: ...[more]