Ontology highlight
ABSTRACT:
SUBMITTER: Culurgioni S
PROVIDER: S-EPMC5844954 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Culurgioni Simone S Mari Sara S Bonetti Paola P Gallini Sara S Bonetto Greta G Brennich Martha M Round Adam A Nicassio Francesco F Mapelli Marina M
Nature communications 20180309 1
Asymmetric cell divisions balance stem cell proliferation and differentiation to sustain tissue morphogenesis and homeostasis. During asymmetric divisions, fate determinants and niche contacts segregate unequally between daughters, but little is known on how this is achieved mechanistically. In Drosophila neuroblasts and murine mammary stem cells, the association of the spindle orientation protein LGN with the stem cell adaptor Inscuteable has been connected to asymmetry. Here we report the crys ...[more]