Ambient temperature and biomarkers of heart failure: a repeated measures analysis.

ABSTRACT:

Background

Extreme temperatures have been associated with hospitalization and death among individuals with heart failure, but few studies have explored the underlying mechanisms.

Objectives

We hypothesized that outdoor temperature in the Boston, Massachusetts, area (1- to 4-day moving averages) would be associated with higher levels of biomarkers of inflammation and myocyte injury in a repeated-measures study of individuals with stable heart failure.

Methods

We analyzed data from a completed clinical trial that randomized 100 patients to 12 weeks of tai chi classes or to time-matched education control. B-type natriuretic peptide (BNP), C-reactive protein (CRP), and tumor necrosis factor (TNF) were measured at baseline, 6 weeks, and 12 weeks. Endothelin-1 was measured

SUBMITTER: Wilker EH 

PROVIDER: S-EPMC3440076 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature