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Reproducibility of novel immune-inflammatory biomarkers over 4 months: an analysis with repeated measures design.


ABSTRACT: Aim: Assessment of the feasibility and reliability of immune-inflammatory biomarker measurements. Methods: The following biomarkers were assessed in 207 predominantly healthy participants at baseline and after 4 months: MMF, TGF-?, suPAR and clusterin. Results: Intraclass correlation coefficients (95% CIs) ranged from good for TGF-? (0.75 [95% CI: 0.33-0.90]) to excellent for MMF (0.81 [95% CI: 0.64-0.90]), clusterin (0.83 [95% CI: 0.78-0.87]) and suPAR (0.91 [95% CI: 0.88-0.93]). Measurement of TGF-? was challenged by the large number of values below the detection limit. Conclusion: Single measurements of suPAR, clusterin and MMF could serve as feasible and reliable biomarkers of immune-inflammatory pathways in biomedical research.

SUBMITTER: Schenk M 

PROVIDER: S-EPMC6630486 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Reproducibility of novel immune-inflammatory biomarkers over 4 months: an analysis with repeated measures design.

Schenk Matthew M   Eichelmann Fabian F   Schulze Matthias B MB   Rudovich Natalia N   Pfeiffer Andreas F AF   di Giuseppe Romina R   Boeing Heiner H   Aleksandrova Krasimira K  

Biomarkers in medicine 20190603 8


<b>Aim:</b> Assessment of the feasibility and reliability of immune-inflammatory biomarker measurements. <b>Methods:</b> The following biomarkers were assessed in 207 predominantly healthy participants at baseline and after 4 months: MMF, TGF-β, suPAR and clusterin. <b>Results:</b> Intraclass correlation coefficients (95% CIs) ranged from good for TGF-β (0.75 [95% CI: 0.33-0.90]) to excellent for MMF (0.81 [95% CI: 0.64-0.90]), clusterin (0.83 [95% CI: 0.78-0.87]) and suPAR (0.91 [95% CI: 0.88-0  ...[more]

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