Ontology highlight
ABSTRACT:
SUBMITTER: Zhou XJ
PROVIDER: S-EPMC3442876 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Autophagy 20120814 9
Autophagy is now emerging as a spotlight in trafficking events that activate innate and adaptive immunity. It facilitates innate pathogen detection and antigen presentation, as well as pathogen clearance and lymphocyte homeostasis. In this review, we first summarize new insights into its functions in immunity, which underlie its associations with autoimmunity. As some lines of evidence are emerging to support its role in autoimmune and autoinflammatory diseases, we further discuss whether and ho ...[more]