Ontology highlight
ABSTRACT:
SUBMITTER: Tazumi A
PROVIDER: S-EPMC3444731 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Tazumi Atsutoshi A Fukuura Masayoshi M Nakato Ryuichiro R Kishimoto Ami A Takenaka Tomokazu T Ogawa Shiho S Song Ji-Hoon JH Takahashi Tatsuro S TS Nakagawa Takuro T Shirahige Katsuhiko K Masukata Hisao H
Genes & development 20120901 18
In eukaryotes, the replication of chromosome DNA is coordinated by a replication timing program that temporally regulates the firing of individual replication origins. However, the molecular mechanism underlying the program remains elusive. Here, we report that the telomere-binding protein Taz1 plays a crucial role in the control of replication timing in fission yeast. A DNA element located proximal to a late origin in the chromosome arm represses initiation from the origin in early S phase. Sys ...[more]