Ontology highlight
ABSTRACT:
SUBMITTER: Santanam U
PROVIDER: S-EPMC4762425 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Santanam Urmila U Banach-Petrosky Whitney W Abate-Shen Cory C Shen Michael M MM Shen Michael M MM White Eileen E DiPaola Robert S RS
Genes & development 20160201 4
Understanding new therapeutic paradigms for both castrate-sensitive and more aggressive castrate-resistant prostate cancer is essential to improve clinical outcomes. As a critically important cellular process, autophagy promotes stress tolerance by recycling intracellular components to sustain metabolism important for tumor survival. To assess the importance of autophagy in prostate cancer, we generated a new autochthonous genetically engineered mouse model (GEMM) with inducible prostate-specifi ...[more]