Ontology highlight
ABSTRACT:
SUBMITTER: Brayman MJ
PROVIDER: S-EPMC3447085 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Brayman Melissa J MJ Pepa Patricia A PA Mellon Pamela L PL
Molecular and cellular endocrinology 20120802 1-2
Gonadotropin-releasing hormone (GnRH) plays a major role in the hypothalamic-pituitary-gonadal (HPG) axis, and synthesis and secretion of GnRH are regulated by gonadal steroid hormones. Disruptions in androgen levels are involved in a number of reproductive defects, including hypogonadotropic hypogonadism and polycystic ovarian syndrome. Androgens down-regulate GnRH mRNA synthesis in vivo and in vitro via an androgen receptor (AR)-dependent mechanism. Methyltrienolone (R1881), a synthetic AR ago ...[more]