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Parallel solid-phase synthesis of diaryltriazoles.

ABSTRACT: A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors for protein-protein interactions.

SUBMITTER: Wrobel M

PROVIDER: S-EPMC3458720 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Parallel solid-phase synthesis of diaryltriazoles.

Wrobel Matthias M Aubé Jeffrey J König Burkhard B

Beilstein journal of organic chemistry 20120706

A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors fo ...[more]

PMID: 23019430

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