Unknown

Dataset Information

0

Parallel solid-phase synthesis of diaryltriazoles.


ABSTRACT: A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors for protein-protein interactions.

SUBMITTER: Wrobel M 

PROVIDER: S-EPMC3458720 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

altmetric image

Publications

Parallel solid-phase synthesis of diaryltriazoles.

Wrobel Matthias M   Aubé Jeffrey J   König Burkhard B  

Beilstein journal of organic chemistry 20120706


A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors fo  ...[more]

Similar Datasets

| S-EPMC6268589 | biostudies-other
| S-EPMC2652863 | biostudies-literature
| S-EPMC3875618 | biostudies-literature
| S-EPMC8672447 | biostudies-literature
| S-EPMC3718127 | biostudies-literature
| S-EPMC2702710 | biostudies-literature
2023-03-02 | PXD039931 | Pride
| S-EPMC6269862 | biostudies-literature
| S-EPMC4135478 | biostudies-literature
| S-EPMC4201324 | biostudies-literature