Dataset Information

Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis.

ABSTRACT: BACKGROUND: The gene encoding CD14 has been proposed as an IBD-susceptibility gene with its polymorphism C-260T being widely evaluated, yet with conflicting results. The aim of this study was to investigate the association between this polymorphism and IBD by conducting a meta-analysis. METHODOLOGY/PRINCIPAL FINDINGS: Seventeen articles met the inclusion criteria, which included a total of 18 case-control studies, including 1900 ulcerative colitis (UC) cases, 2535 Crohn's disease (CD) cases, and 4004 controls. Data were analyzed using STATA software. Overall, association between C-260T polymorphism and increased UC risk was significant in allelic comparison (odds ratio [OR] ?=1.21, 95% confidence interval [CI]: 1.02-1.43; P=0.027), homozygote model (OR ?=1.44, 95% CI: 1.03-2.01; P=0.033), as well as dominant model (OR ?=1.36, 95% CI: 1.06-1.75; P=0.016). However, there was negative association between this polymorphism and CD risk across all genetic models. Subgroup analyses by ethnicity suggested the risk-conferring profiles of -260T allele and -260 TT genotype with UC in Asians, but not in Caucasians. There was a low probability of publication bias. CONCLUSIONS/SIGNIFICANCE: Expanding previous results of individual studies, our findings demonstrated that CD14 gene C-260T polymorphism might be a promising candidate marker in susceptibility to UC, especially in Asians.

SUBMITTER: Wang Z

PROVIDER: S-EPMC3458839 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis.

Wang Zhengting Z Hu Jiajia J Fan Rong R Zhou Jie J Zhong Jie J

PloS one 20120926 9

<h4>Background</h4>The gene encoding CD14 has been proposed as an IBD-susceptibility gene with its polymorphism C-260T being widely evaluated, yet with conflicting results. The aim of this study was to investigate the association between this polymorphism and IBD by conducting a meta-analysis.<h4>Methodology/principal findings</h4>Seventeen articles met the inclusion criteria, which included a total of 18 case-control studies, including 1900 ulcerative colitis (UC) cases, 2535 Crohn's disease (C ...[more]

PMID: 23049772

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Project description:BackgroundThe association between CD14-159C/T polymorphism and sepsis has been assessed but results of current studies appeared conflicting and inconstant. This analysis was aimed to determine whether the CD14-159C/T polymorphism confers susceptibility to sepsis or is associated with increased risk of death from sepsis.MethodThe authors conducted a comprehensive search of PubMed, EMBASE, ISI Web of Science, Cochrane library, ScienceDirect, Wiley Online Library and CNKI databases according to a prespecified protocol. Language limits were restricted to English and Chinese. Two reviewers independently selected the articles and extracted relevant data onto standardized forms. Disagreements were settled by discussion and suggestions from senior consultants. The strength of association were evaluated by odds ratio (OR) and 95% confidence interval (CI). Studies failed to fit the Hardy-Weinberg-Equilibrium were excluded.ResultsThe research identified a total of 2317 full-text articles of which 14 articles met the predefined inclusion criteria. Meta-analysis was performed for allele frequency of C versus T, as well as genotypes CC?+?CT versus TT (dominant model), CC versus TT?+?CT (recessive model), CT versus TT and CC versus TT (additive model). All control samples were in Hardy-Weinberg proportion. No significant association between CD14-159C/T polymorphism and sepsis susceptibility or mortality were detected in the overall population. Nonetheless, subgroup analysis of Asian ethnicity revealed significant association between the CD14-159C/T polymorphism and susceptibility to sepsis in additive model (CC versus TT: OR?=?0.52, 95% CI 0.29-0.92, p?=?0.03) and recessive model (CC versus CT?+?TT: OR?=?0.50, 95% CI 0.30-0.84, p?=?0.009). Of note, three out of the five papers included in the subgroup focused exclusively on burn ICU patients.ConclusionsThis meta-analysis demonstrated that CD14-159C/T polymorphism is likely to be associated with susceptibility to sepsis in Asian population, especially for the TT genotype. However, bias may rise for etiologic reasons because the majority of subjects in the subgroup came from burn ICU. CD14-159C/T polymorphism is not relevant to sepsis mortality in any genetic models, regardless of the ethnicities. Due to the exploratory nature of the study, no adjustment for multiple testing was adopted, and therefore the results should be interpreted with precaution. Well-designed studies with larger sample size and more ethnic groups are required to further validate the results.

Dataset Information

Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis.

Publications

Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis.

Similar Datasets

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