Ontology highlight
ABSTRACT:
SUBMITTER: Salter MD
PROVIDER: S-EPMC3460423 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Salter Mallory D MD Blouin George C GC Soman Jayashree J Singleton Eileen W EW Dewilde Sylvia S Moens Luc L Pesce Alessandra A Nardini Marco M Bolognesi Martino M Olson John S JS
The Journal of biological chemistry 20120801 40
Although molecular dynamics simulations suggest multiple interior pathways for O(2) entry into and exit from globins, most experiments indicate well defined single pathways. In 2001, we highlighted the effects of large-to-small amino acid replacements on rates for ligand entry and exit onto the three-dimensional structure of sperm whale myoglobin. The resultant map argued strongly for ligand movement through a short channel from the heme iron to solvent that is gated by the distal histidine (His ...[more]