Ontology highlight
ABSTRACT:
SUBMITTER: Cooper S
PROVIDER: S-EPMC4710245 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20150826 22
Melanoma cells can adopt two functionally distinct forms, amoeboid and mesenchymal, which facilitates their ability to invade and colonize diverse environments during the metastatic process. Using quantitative imaging of single living tumor cells invading three-dimensional collagen matrices, in tandem with unsupervised computational analysis, we found that melanoma cells can switch between amoeboid and mesenchymal forms via two different routes in shape space--an apolar and polar route. We show ...[more]