Ontology highlight
ABSTRACT:
SUBMITTER: Tseng JH
PROVIDER: S-EPMC5578720 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Tseng Jui-Heng JH Xie Ling L Song Sheng S Xie Youmei Y Allen Lauren L Ajit Deepa D Hong Jau-Shyong JS Chen Xian X Meeker Rick B RB Cohen Todd J TJ
Cell reports 20170801 9
The initiating events that promote tau mislocalization and pathology in Alzheimer's disease (AD) are not well defined, partly because of the lack of endogenous models that recapitulate tau dysfunction. We exposed wild-type neurons to a neuroinflammatory trigger and examined the effect on endogenous tau. We found that tau re-localized and accumulated within pathological neuritic foci, or beads, comprised of mostly hypo-phosphorylated, acetylated, and oligomeric tau. These structures were detected ...[more]