SQID-XLink: implementation of an intensity-incorporated algorithm for cross-linked peptide identification.
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ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC3463113 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
SQID-XLink: implementation of an intensity-incorporated algorithm for cross-linked peptide identification.
Li Wenzhou W O'Neill Heather A HA Wysocki Vicki H VH
Bioinformatics (Oxford, England) 20120712 19
<h4>Summary</h4>Peptide identification algorithm is a major bottleneck for mass spectrometry based chemical cross-linking experiments. Our lab recently developed an intensity-incorporated peptide identification algorithm, and here we implemented this scheme for cross-linked peptide discovery. Our program, SQID-XLink, searches all regular, dead-end, intra and inter cross-linked peptides simultaneously, and its effectiveness is validated by testing a published dataset. This new algorithm provides ...[more]
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