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Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors.

ABSTRACT: Macrophage scavenger receptors appear to play a major role in the clearance of oxidized phospholipid (OxPL) products. Discrete peptide-phospholipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity for these receptors. We report the preparation of a water-soluble, stable peptide-phospholipid conjugate (9) that possesses the necessary physical properties to enable more detailed study of the role(s) of OxPL in metabolic disease.

SUBMITTER: Turner WW

PROVIDER: S-EPMC3465084 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors.

Turner William W WW Hartvigsen Karsten K Boullier Agnes A Montano Erica N EN Witztum Joseph L JL VanNieuwenhze Michael S MS

Journal of medicinal chemistry 20120911 18

Macrophage scavenger receptors appear to play a major role in the clearance of oxidized phospholipid (OxPL) products. Discrete peptide-phospholipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity for these receptors. We report the preparation of a water-soluble, stable peptide-phospholipid conjugate (9) that possesses the necessary physical properties to enable more detailed study of the role(s) of OxPL in metabolic disease. ...[more]

PMID: 22934615

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2014-10-17 | E-GEOD-62434 | biostudies-arrayexpress

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