Ontology highlight
ABSTRACT:
SUBMITTER: Dai Z
PROVIDER: S-EPMC6256357 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Dai Zhefu Z Zhang Xiao-Nan XN Nasertorabi Fariborz F Cheng Qinqin Q Pei Hua H Louie Stan G SG Stevens Raymond C RC Zhang Yong Y
Chemical science 20181015 44
Nicotinamide adenine dinucleotide (NAD<sup>+</sup>) is an essential cofactor participating in a variety of important enzyme-catalyzed physiological and pathophysiological processes. Analogues of NAD<sup>+</sup> provide key and valuable agents for investigating NAD<sup>+</sup>-dependent enzymes. In this study, we report the preparation of a novel stable NAD<sup>+</sup> mimic, 4'-thioribose NAD<sup>+</sup> (S-NAD<sup>+</sup>), using a facile and efficient chemoenzymatic approach. Substrate activit ...[more]