Ontology highlight
ABSTRACT:
SUBMITTER: Ciccarone F
PROVIDER: S-EPMC3465317 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ciccarone Fabio F Klinger Francesca Gioia FG Catizone Angela A Calabrese Roberta R Zampieri Michele M Bacalini Maria Giulia MG De Felici Massimo M Caiafa Paola P
PloS one 20121005 10
Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA methylation patterns controlling transcription and activity of Dnmt1. Here, we show that ADP-ribose polymer levels and Parp1 expression are noticeably high in mouse primordial germ cells (PGCs) when the bulk of DNA demethylation occurs during germline epigenetic reprogramming in the embryo. Notably, Parp1 activity is stimulated in PGCs even befo ...[more]