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Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds.

ABSTRACT: License to fuse! A phosphorylated fusion peptide can mediate membrane fusion when the phosphates (green triangles, see scheme) are removed by phosphatases (blue spheres), delivering the contents of the liposome into the cytosol. This phosphatase-triggered approach may be useful to create target-specific lipid nanocarriers.

SUBMITTER: Motion JP

PROVIDER: S-EPMC3470804 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds.

Motion J P Michael JP Nguyen Juliane J Szoka Francis C FC

Angewandte Chemie (International ed. in English) 20120806 36

License to fuse! A phosphorylated fusion peptide can mediate membrane fusion when the phosphates (green triangles, see scheme) are removed by phosphatases (blue spheres), delivering the contents of the liposome into the cytosol. This phosphatase-triggered approach may be useful to create target-specific lipid nanocarriers. ...[more]

PMID: 22887437

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