Ontology highlight
ABSTRACT:
SUBMITTER: Binder JT
PROVIDER: S-EPMC3474870 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20121005 41
We have developed a nickel-catalyzed method for the asymmetric cross-coupling of secondary electrophiles with secondary nucleophiles, specifically, stereoconvergent Negishi reactions of racemic benzylic bromides with achiral cycloalkylzinc reagents. In contrast to most previous studies of enantioselective Negishi cross-couplings, tridentate pybox ligands are ineffective in this process; however, a new, readily available bidentate isoquinoline-oxazoline ligand furnishes excellent ee's and good yi ...[more]