Ontology highlight
ABSTRACT:
SUBMITTER: Zhong B
PROVIDER: S-EPMC3477275 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Zhong Bo B Liu Xikui X Wang Xiaohu X Chang Seon Hee SH Liu Xindong X Wang Aibo A Reynolds Joseph M JM Dong Chen C
Nature immunology 20121007 11
Interleukin 17 (IL-17) is important in infection and autoimmunity; how it signals remains poorly understood. In this study, we identified the ubiquitin-specific protease USP25 as a negative regulator of IL-17-mediated signaling and inflammation. Overexpression of USP25 inhibited IL-17-triggered signaling, whereas USP25 deficiency resulted in more phosphorylation of the inhibitor IκBα and kinase Jnk and higher expression of chemokines and cytokines, as well as a prolonged half-life for chemokine ...[more]