Ontology highlight
ABSTRACT:
SUBMITTER: Coles CH
PROVIDER: S-EPMC4765084 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Coles Charlotte H CH Jones E Yvonne EY Aricescu A Radu AR
Seminars in cell & developmental biology 20140916
The receptor protein tyrosine phosphatases (RPTPs) exhibit a wide repertoire of cellular signalling functions. In particular, type IIa RPTP family members have recently been highlighted as hubs for extracellular interactions in neurons, regulating neuronal extension and guidance, as well as synaptic organisation. In this review, we will discuss the recent progress of structural biology investigations into the architecture of type IIa RPTP ectodomains and their interactions with extracellular lig ...[more]