Ontology highlight
ABSTRACT:
SUBMITTER: Vasilescu DM
PROVIDER: S-EPMC3479519 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Vasilescu Dragoş M DM Gao Zhiyun Z Saha Punam K PK Yin Leilei L Wang Ge G Haefeli-Bleuer Beatrice B Ochs Matthias M Weibel Ewald R ER Hoffman Eric A EA
Proceedings of the National Academy of Sciences of the United States of America 20121001 42
Establishing the 3D architecture and morphometry of the intact pulmonary acinus is an essential step toward a more complete understanding of the relationship of lung structure and function. We combined a special fixation method with a unique volumetric nondestructive imaging technique and image processing tools to separate individual acini in the mouse lung. Interior scans of the parenchyma at a resolution of 2 µm enabled the reconstruction and quantitative study of whole acini by image analysis ...[more]