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Solid-phase synthesis of lysobactin (katanosin B): insights into structure and function.

ABSTRACT: The solid phase synthesis of the cyclic depsipeptide antibiotic lysobactin is described. The natural product was synthesized via a linear approach using mostly an Fmoc-strategy solid phase peptide synthesis (SPPS) with a single purification. A lysobactin analog has also been synthesized displaying nanomolar membrane disruption activity not seen with the natural product.

SUBMITTER: Hall EA

PROVIDER: S-EPMC3488444 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Solid-phase synthesis of lysobactin (katanosin B): insights into structure and function.

Hall Edward A EA Kuru Erkin E VanNieuwenhze Michael S MS

Organic letters 20120521 11

The solid phase synthesis of the cyclic depsipeptide antibiotic lysobactin is described. The natural product was synthesized via a linear approach using mostly an Fmoc-strategy solid phase peptide synthesis (SPPS) with a single purification. A lysobactin analog has also been synthesized displaying nanomolar membrane disruption activity not seen with the natural product. ...[more]

PMID: 22612400

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