Ontology highlight
ABSTRACT:
SUBMITTER: Shashilov V
PROVIDER: S-EPMC3490051 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Shashilov Victor V Xu Ming M Makarava Natallia N Savtchenko Regina R Baskakov Ilia V IV Lednev Igor K IK
The journal of physical chemistry. B 20120626 27
The molecular mechanisms underlying structural diversity of amyloid fibrils or prion strains formed within the same primary structure is considered to be one of the most enigmatic questions in prion biology. We report here on the direct characterization of amyloid structures using a novel spectroscopic technique, hydrogen-deuterium exchange ultraviolet Raman spectroscopy. This method enables us to assess the structural differences within highly ordered cross-β-cores of two amyloid states produce ...[more]