Interleukin-6--a key regulator of colorectal cancer development.
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ABSTRACT:
SUBMITTER: Waldner MJ
PROVIDER: S-EPMC3491448 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Interleukin-6--a key regulator of colorectal cancer development.
Waldner Maximilian J MJ Foersch Sebastian S Neurath Markus F MF
International journal of biological sciences 20121024 9
Growing evidence proposes an important role for pro-inflammatory cytokines during tumor development. Several experimental and clinical studies have linked the pleiotropic cytokine interleukin-6 (IL-6) to the pathogenesis of sporadic and inflammation-associated colorectal cancer (CRC). Increased IL-6 expression has been related to advanced stage of disease and decreased survival in CRC patients. According to experimental studies, these effects are mediated through IL-6 trans-signaling promoting t ...[more]
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