Ontology highlight
ABSTRACT:
SUBMITTER: Lee E
PROVIDER: S-EPMC5389554 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Lee Eunhye E Lee Taeyun A TA Kim Ji Hyun JH Park Areum A Ra Eun A EA Kang Sujin S Choi Hyun Jin HJ Choi Junhee L JL Huh Hyunbin D HD Lee Ji Eun JE Lee Sungwook S Park Boyoun B
Nucleic acids research 20170401 6
The transcription of inflammatory genes is an essential step in host defense activation. Here, we show that cellular nucleic acid-binding protein (CNBP) acts as a transcription regulator that is required for activating the innate immune response. We identified specific CNBP-binding motifs present in the promoter region of sustained inflammatory cytokines, thus, directly inducing the expression of target genes. In particular, lipopolysaccharide (LPS) induced cnbp expression through an NF-κB-depen ...[more]