Ontology highlight
ABSTRACT:
SUBMITTER: Gavara N
PROVIDER: S-EPMC3492504 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Gavara Núria N Chadwick Richard S RS
Nature nanotechnology 20120930 11
The atomic force microscope can detect the mechanical fingerprints of normal and diseased cells at the single-cell level under physiological conditions. However, atomic force microscopy studies of cell mechanics are limited by the 'bottom effect' artefact that arises from the stiff substrates used to culture cells. Because cells adhered to substrates are very thin, this artefact makes cells appear stiffer than they really are. Here, we show an analytical correction that accounts for this artefac ...[more]