Ontology highlight
ABSTRACT:
SUBMITTER: Villarreal DD
PROVIDER: S-EPMC3493447 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PLoS genetics 20121108 11
Chromosomal structural change triggers carcinogenesis and the formation of other genetic diseases. The breakpoint junctions of these rearrangements often contain small overlapping sequences called "microhomology," yet the genetic pathway(s) responsible have yet to be defined. We report a simple genetic system to detect microhomology-mediated repair (MHMR) events after a DNA double-strand break (DSB) in budding yeast cells. MHMR using >15 bp operates as a single-strand annealing variant, requirin ...[more]