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Nickel-mediated oxidative fluorination for PET with aqueous [18F] fluoride.

ABSTRACT: A one-step oxidative fluorination for carbon-fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical (18)F late-stage fluorination of complex small molecules with potential for PET imaging.

SUBMITTER: Lee E 

PROVIDER: S-EPMC3494465 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Nickel-mediated oxidative fluorination for PET with aqueous [18F] fluoride.

Lee Eunsung E   Hooker Jacob M JM   Ritter Tobias T  

Journal of the American Chemical Society 20121012 42

A one-step oxidative fluorination for carbon-fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical (18)F late-stage fluorination of complex small molecules with potential for PET imaging. ...[more]

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