Ontology highlight
ABSTRACT:
SUBMITTER: Brandt JR
PROVIDER: S-EPMC3870902 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Chemical science 20140101 1
Electrophilic fluorinating reagents derived from fluoride are desirable for the synthesis of <sup>18</sup>F-labeled molecules for positron emission tomography (PET). Here, we study the mechanism by which a Pd(IV)-complex captures fluoride and subsequently transfers it to nucleophiles. The intermediate Pd(IV)-F is formed with high rates even at the nano- to micromolar fluoride concentrations typical for radiosyntheses with <sup>18</sup>F due to fast formation of an outer-sphere complex between fl ...[more]