Ontology highlight
ABSTRACT:
SUBMITTER: Mitrovich QM
PROVIDER: S-EPMC3496775 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Mitrovich Quinn M QM Tuch Brian B BB De La Vega Francisco M FM Guthrie Christine C Johnson Alexander D AD
Science (New York, N.Y.) 20101101 6005
The evolutionary forces responsible for intron loss are unresolved. Whereas research has focused on protein-coding genes, here we analyze noncoding small nucleolar RNA (snoRNA) genes in which introns, rather than exons, are typically the functional elements. Within the yeast lineage exemplified by the human pathogen Candida albicans, we find--through deep RNA sequencing and genome-wide annotation of splice junctions--extreme compaction and loss of associated exons, but retention of snoRNAs withi ...[more]