Ontology highlight
ABSTRACT:
SUBMITTER: Wan Y
PROVIDER: S-EPMC3498495 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Wan Yuan Y Liu Yaling Y Allen Peter B PB Asghar Waseem W Mahmood M Arif Iftakher MA Tan Jifu J Duhon Holli H Kim Young-tae YT Ellington Andrew D AD Iqbal Samir M SM
Lab on a chip 20121101 22
Early detection and isolation of circulating tumor cells (CTC) can enable better prognosis for cancer patients. A Hele-Shaw device with aptamer functionalized glass beads is designed, modeled, and fabricated to efficiently isolate cancer cells from a cellular mixture. The glass beads are functionalized with anti-epidermal growth factor receptor (EGFR) aptamer and sit in ordered array of pits in polydimethylsiloxane (PDMS) channel. A PDMS encapsulation is then used to cover the channel and to flo ...[more]