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Advances in Targeting HER3 as an Anticancer Therapy.

ABSTRACT: HER3 (ErbB3) is a unique member of the human epidermal growth factor receptor (EGFR) family (ErbB family). It functions only through dimerization with other members of the ErbB family and modulates activity and sensitivity to targeted cancer therapies. This paper briefly describes the mechanism of HER3 in signal transduction and its potential role in acquired resistance to EGFR- and HER2-targeted therapies. We also consider recent developments in HER3-targeting therapeutics and their combination with inhibitors of other ErbB members in clinical applications.

SUBMITTER: Jiang N

PROVIDER: S-EPMC3502787 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Advances in Targeting HER3 as an Anticancer Therapy.

Jiang Ning N Saba Nabil F NF Chen Zhuo Georgia ZG

Chemotherapy research and practice 20121107

HER3 (ErbB3) is a unique member of the human epidermal growth factor receptor (EGFR) family (ErbB family). It functions only through dimerization with other members of the ErbB family and modulates activity and sensitivity to targeted cancer therapies. This paper briefly describes the mechanism of HER3 in signal transduction and its potential role in acquired resistance to EGFR- and HER2-targeted therapies. We also consider recent developments in HER3-targeting therapeutics and their combination ...[more]

PMID: 23198146

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