Advances in anticancer immunotoxin therapy.
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ABSTRACT:
SUBMITTER: Alewine C
PROVIDER: S-EPMC4319635 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Advances in anticancer immunotoxin therapy.
Alewine Christine C Hassan Raffit R Pastan Ira I
The oncologist 20150105 2
Immunotoxins are a novel class of antibody-conjugated therapeutics currently in clinical development for a variety of malignancies. They consist of an antibody-based targeting domain fused to a bacterial toxin payload for cell killing. Immunotoxins kill cells by inhibiting protein synthesis, a unique mechanism of action that is toxic to both dividing and nondividing cells. Recent advances in the design and administration of immunotoxins are overcoming historical challenges in the field, leading ...[more]
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