Ontology highlight
ABSTRACT:
SUBMITTER: Yu WB
PROVIDER: S-EPMC3503724 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Yu Wen-Bang WB Yin Chun-Yun CY Zhou Ying Y Ye Bang-Ce BC
PloS one 20121121 11
Long-term use of antibiotics has engendered a large number of resistant pathogens, which pose a serious threat to human health. Here, we investigated the mechanism of fusaricidin antibacterial activity toward Bacillus subtilis and characterized the pathways responsible for drug resistance. We found that σ(w), an extracytoplasmic function sigma factor, plays an important role in the resistance to fusaricidins during the initial 5 minutes of drug addition. Approximately 18 genes were induced more ...[more]