Ontology highlight
ABSTRACT:
SUBMITTER: Chipuk JE
PROVIDER: S-EPMC3506012 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Chipuk Jerry E JE McStay Gavin P GP Bharti Archana A Kuwana Tomomi T Clarke Christopher J CJ Siskind Leah J LJ Obeid Lina M LM Green Douglas R DR
Cell 20120301 5
Mitochondria are functionally and physically associated with heterotypic membranes, yet little is known about how these interactions impact mitochondrial outer-membrane permeabilization (MOMP) and apoptosis. We observed that dissociation of heterotypic membranes from mitochondria inhibited BAK/BAX-dependent cytochrome c (cyto c) release. Biochemical purification of neutral sphingomyelinases that correlated with MOMP sensitization suggested that sphingolipid metabolism coordinates BAK/BAX activat ...[more]