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Asymmetric desymmetrization of meso-diols by C(2)-symmetric chiral 4-pyrrolidinopyridines.

ABSTRACT: In this work we developed C(2)-symmetric chiral nucleophilic catalysts which possess a pyrrolidinopyridine framework as a catalytic site. Some of these organocatalysts effectively promoted asymmetric desymmetrization of meso-diols via enantioselective acylation.

SUBMITTER: Schedel H

PROVIDER: S-EPMC3511012 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Asymmetric desymmetrization of meso-diols by C(2)-symmetric chiral 4-pyrrolidinopyridines.

Schedel Hartmut H Kan Keizo K Ueda Yoshihiro Y Mishiro Kenji K Yoshida Keisuke K Furuta Takumi T Kawabata Takeo T

Beilstein journal of organic chemistry 20121017

In this work we developed C(2)-symmetric chiral nucleophilic catalysts which possess a pyrrolidinopyridine framework as a catalytic site. Some of these organocatalysts effectively promoted asymmetric desymmetrization of meso-diols via enantioselective acylation. ...[more]

PMID: 23209512

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