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Total synthesis of (±)-maoecrystal V.

ABSTRACT: The total synthesis of racemic maoecrystal V has been accomplished. Key steps include an intramolecular Diels-Alder cyclization to rapidly construct the core system from simple starting materials and the creation of the A-C ring trans-fusion through intramolecular delivery of a hydrogen to the hindered ?-face of the ring system.

SUBMITTER: Peng F

PROVIDER: S-EPMC3512084 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Total synthesis of (±)-maoecrystal V.

Peng Feng F Danishefsky Samuel J SJ

Journal of the American Chemical Society 20121105 45

The total synthesis of racemic maoecrystal V has been accomplished. Key steps include an intramolecular Diels-Alder cyclization to rapidly construct the core system from simple starting materials and the creation of the A-C ring trans-fusion through intramolecular delivery of a hydrogen to the hindered β-face of the ring system. ...[more]

PMID: 23126440

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