Ontology highlight
ABSTRACT:
SUBMITTER: Romagnoli M
PROVIDER: S-EPMC3513653 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Romagnoli Mathilde M Belguise Karine K Yu Ziyang Z Wang Xiaobo X Landesman-Bollag Esther E Seldin David C DC Chalbos Dany D Barillé-Nion Sophie S Jézéquel Pascal P Seldin Margaret L ML Sonenshein Gail E GE
Cancer research 20121010 23
Induction of epithelial-to-mesenchymal transition (EMT) by TGF-β1 requires Ras signaling. We recently identified the transcriptional repressor Blimp-1 (PRDM1) as a downstream effector of the NF-κB, RelB/Bcl-2/Ras-driven pathway that promotes breast cancer cell migration. As the RelB/Blimp-1 pathway similarly required Ras signaling activation, we tested whether Blimp-1 plays a role in TGF-β1-mediated EMT. Here, TGF-β1 treatment of untransformed NMuMG mammary epithelial and MDA-MB-231 breast cance ...[more]