Ontology highlight
ABSTRACT:
SUBMITTER: Martin CJ
PROVIDER: S-EPMC3517204 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Martin Constance J CJ Booty Matthew G MG Rosebrock Tracy R TR Nunes-Alves Cláudio C Desjardins Danielle M DM Keren Iris I Fortune Sarah M SM Remold Heinz G HG Behar Samuel M SM
Cell host & microbe 20120901 3
Mycobacterium tuberculosis persists within macrophages in an arrested phagosome and depends upon necrosis to elude immunity and disseminate. Although apoptosis of M. tuberculosis-infected macrophages is associated with reduced bacterial growth, the bacteria are relatively resistant to other forms of death, leaving the mechanism underlying this observation unresolved. We find that after apoptosis, M. tuberculosis-infected macrophages are rapidly taken up by uninfected macrophages through efferocy ...[more]