Ontology highlight
ABSTRACT:
SUBMITTER: Nanton MR
PROVIDER: S-EPMC3518619 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20121112 12
Typhoid fever and nontyphoidal bacteremia caused by Salmonella remain critical human health problems. B cells are required for protective immunity to Salmonella, but the mechanism of protection remains unclear. In this study, we immunized wild-type, B cell-deficient, Ab-deficient, and class-switched Ab-deficient mice with attenuated Salmonella and examined protection against secondary infection. As expected, wild-type mice were protected and B cell-deficient mice succumbed to secondary infection ...[more]