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Evolutionary diversity of the mitochondrial calcium uniporter.

ABSTRACT: Calcium uptake into mitochondria occurs via a recently identified ion channel called the uniporter. Here, we characterize the phylogenomic distribution of the uniporter's membrane-spanning pore subunit (MCU) and regulatory partner (MICU1). Homologs of both components tend to co-occur in all major branches of eukaryotic life, but both have been lost along certain protozoan and fungal lineages. Several bacterial genomes also contain putative MCU homologs that may represent prokaryotic calcium channels. The analyses indicate that the uniporter may have been an early feature of mitochondria.

SUBMITTER: Bick AG

PROVIDER: S-EPMC3518847 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Evolutionary diversity of the mitochondrial calcium uniporter.

Bick Alexander G AG Calvo Sarah E SE Mootha Vamsi K VK

Science (New York, N.Y.) 20120501 6083

Calcium uptake into mitochondria occurs via a recently identified ion channel called the uniporter. Here, we characterize the phylogenomic distribution of the uniporter's membrane-spanning pore subunit (MCU) and regulatory partner (MICU1). Homologs of both components tend to co-occur in all major branches of eukaryotic life, but both have been lost along certain protozoan and fungal lineages. Several bacterial genomes also contain putative MCU homologs that may represent prokaryotic calcium chan ...[more]

PMID: 22605770

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