Ontology highlight
ABSTRACT:
SUBMITTER: Fernhoff NB
PROVIDER: S-EPMC3522300 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Fernhoff Nathaniel B NB Derbyshire Emily R ER Underbakke Eric S ES Marletta Michael A MA
The Journal of biological chemistry 20121023 51
Nitric oxide (NO) signaling regulates key processes in cardiovascular physiology, specifically vasodilation, platelet aggregation, and leukocyte rolling. Soluble guanylate cyclase (sGC), the mammalian NO sensor, transduces an NO signal into the classical second messenger cyclic GMP (cGMP). NO binds to the ferrous (Fe(2+)) oxidation state of the sGC heme cofactor and stimulates formation of cGMP several hundred-fold. Oxidation of the sGC heme to the ferric (Fe(3+)) state desensitizes the enzyme t ...[more]