Ontology highlight
ABSTRACT:
SUBMITTER: Shah NB
PROVIDER: S-EPMC3524348 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Shah Neha B NB Vercellotti Gregory M GM White James G JG Fegan Adrian A Wagner Carston R CR Bischof John C JC
Molecular pharmaceutics 20120723 8
Theranostic nanoparticles (NPs) cannot reach their target tissue without first passing through blood; however, the influence of blood protein and blood cell interactions on NP biodistribution are not well understood. The current work shows that 30 nm PEGylated gold NPs (GNPs) interact not only with blood proteins as thought before but also with blood cells (especially platelets and monocytes) in vivo and that longer blood circulation correlates strongly with tumor uptake. Further, GNP surface pr ...[more]