Ontology highlight
ABSTRACT:
SUBMITTER: Groom JR
PROVIDER: S-EPMC3525757 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Groom Joanna R JR Richmond Jillian J Murooka Thomas T TT Sorensen Elizabeth W EW Sung Jung Hwan JH Bankert Katherine K von Andrian Ulrich H UH Moon James J JJ Mempel Thorsten R TR Luster Andrew D AD
Immunity 20121101 6
Differentiation of naive CD4(+) T cells into T helper (Th) cells is a defining event in adaptive immunity. The cytokines and transcription factors that control Th cell differentiation are understood, but it is not known how this process is orchestrated within lymph nodes (LNs). Here we have shown that the CXCR3 chemokine receptor was required for optimal generation of interferon-γ (IFN-γ)-secreting Th1 cells in vivo. By using a CXCR3 ligand reporter mouse, we found that stromal cells predominate ...[more]